The Science Behind Chew O

Where Nature Meets Scientific Proof

Why PE0301? 

The most common and easily thought of oral care products are typically mouthwash and toothpaste. But, did you know? These daily essentials often contain fluoride, which, while effective in killing both beneficial and harmful bacteria, can disrupt the balance of oral microbiota. On the other hand, many stomach health products are medications with side effects, damaging the stomach mucosa and then weakening the digestive and immune system. 


PE0301 is a blend of Postbiotics with selected strains, known for its potential to combat bad breath or halitosis. Halitosis is a condition characterized by persistent unpleasant breath odor. It can arise from various factors, including poor oral hygiene, gum disease, dental infections, dry mouth, smoking, certain foods, and underlying medical conditions. 

Totipro® Postbiotics PE0301 Blend 

  • Lactobacillus plantarum LPL28
  • Lactobacillus salivarius AP-32
  • Lactobacillus paracasei ET-66 

Here's how PE0301 may help to treat halitosis: 

Targeting harmful oral bacteria while supporting a balanced, healthier microbiome.

Bacterial Reduction

Targets the root cause of bad breath by inhibiting odor-producing bacteria.

PE0301 has been studied for its ability to inhibit the growth of odor-producing bacteria in the mouth, particularly those involved in the breakdown of proteins into volatile sulfur compounds (VSCs), which contribute to halitosis. By reducing the population of these bacteria, PE0301 may help alleviate bad breath.

Oral Health Benefits

Promotes a balanced oral microbiome for lasting freshness.

Streptococcus salivarius, the bacterium from which PE0301 is derived, is a naturally occurring resident of the oral microbiota and is known for its probiotic properties. It competes with harmful bacteria for resources and space in the oral cavity, thereby promoting oral health. By fostering a healthier balance of oral microorganisms, PE0301 may contribute to fresher breath.

Immunology Benefits

Strengthens oral and digestive immunity for overall protection.

It naturally boosts immunity by elevating saliva IgA levels, optimizing oral microbiota, enhancing mouth and stomach mucosa, and preventing acid reflux.

Clinical Studies

Research on PE0301's efficacy in addressing halitosis is ongoing. Clinical trials and studies aim to evaluate its safety, effectiveness, and optimal dosage for managing bad breath. Preliminary findings suggest that PE0301 shows promise as a potential therapeutic agent for halitosis management.

Papers and Patents

  • 13+ Science Studies, included in SCI database 
  • 15+ Worldwide Patents in the USA, EU, JP, TW, CN 

Complementary Approach

PE0301 may complement traditional oral hygiene practices, such as brushing, flossing, and using mouthwash, in combating halitosis. Incorporating PE0301-containing products into daily oral care routines could offer an additional layer of protection against bad breath, especially for individuals prone to persistent halitosis.

Why MUCOSAVEâ„¢ FG

MUCOSAVEâ„¢ FG is a unique blend of prickly pear cladodes (Opuntia cus indica L.) and olive leaf (Olea europaea L.) extracts, rich in polysaccharides and biophenols. Clinically developed for mucosal protection, it helps counteract key symptoms of gastrointestinal disorders.

WHAT IT DOES 

MUCOSAVE™ FG has a strong mucoadhesive ability thanks to the Opuntia polysaccharides and a lenitive effect from olive biophenols to protect the sensitive mucosae. Thanks to this combination, MUCOSAVE™ FG improves gastrointestinal disorder and counteracts gastroesophageal reflux. 

MUCOSAVE™ FG ingredient is able to protect mucosal tissue by several mechanism: 

  1. Forms a protective layer to guard mucosa from acid damage 
  2. Helps reduce GERD symptoms and soothe the stomach 
  3. Anti-inflammatory and antimicrobial effects to support oral and digestive wellness 

MUCOSAVEâ„¢ FG application:

  1. Counteract Intestinal disorders and gastroesophageal reflux (GERD)
  2. Improve Digestive Health
  3. Oral care and sensitive Mucosae

  • Impact of the food grade heat-killed probiotic and postbiotic oral lozenges in oral hygiene

    The oral cavity plays a crucial role in food digestion and immune protection. Thus, maintaining oral health is necessary. Postbiotic and heat-killed probiotic cells have shown increased antibacterial potential with stable viability compared with live strains. However, clinical evidence regarding their effect on oral health is insufficient.

    Read our published research 

  • Antibacterial activity of viable and heat-killed probiotic strains against oral pathogens

    Probiotics can stabilize gut flora, regulate intestinal immunity and protect the host from enteric diseases; however, their roles in oral health have received little attention compared to their roles in gut health. Nowadays, the prevalence of sugar-sweetened foods and abuse of antibiotics contribute towards dysbiosis of oral microbiota and drug resistance development in oral pathogens, resulting in various intractable oral diseases.

    Read our published research 

  • Lozenges with probiotic strains enhance oral immune response and health

    Probiotics participate in regulating oral microbiota and reducing the prevalence of oral diseases; however, clinical research on probiotics is insufficient. Therefore, in this study, we performed in vitro screening of potential oral protective probiotic strains and then evaluated the clinical efficacy of the selected strains on maintaining oral health.

    Read our published research 

  • Viable and Heat‑Killed Probiotic Strains Improve Oral Immunity by Elevating the IgA Concentration in the Oral Mucosa

    Oral-nasal mucosal immunity plays a crucial role in protecting the body against bacterial and viral invasion. Safe probiotic products have been used to enhance human immunity and oral health. In this study, we verified the beneficial effects of mixed viable probiotic tablets, consisting of Lactobacillus salivarius subsp.

    Read our published research